Dr Billy Sands
I have a degree in parasitology, which I chose through an interest in understanding how parasites are adapted to survive in their hosts. This led to a PhD on the interaction between host derived serotonin and the tegument of Schistosoma mansoni. After this, I took a postdoctoral position on macrophage activation, which allowed me some opportunity to investigate how the lipophosphoglycan of Leishmania species can suppress macrophage activation and thus enhance parasite survival. This work introduced me to the topic of transcriptional regulation of gene expression, resulting in a move to St Andrews to work on the post translational regulation of the transcription factor NFkB. After this I moved back to Glasgow to work on the regulation of cardiovascular inflammation, induced by cytokines and bacterial products, and its regulation by adenosine. This led on to further projects looking at regulation of steroidogenesis, stem cell fate decision making and proteostatic mechanisms in relation to dietary intake and ageing.
I have now finally returned to the world of parasitology where my main project is to isolate microfilaria of Onchocerca volvulus for genome sequencing. This is part of a study to infer the parenthood of microfilaria from infected individuals before and after ivermectin treatment to determine whether the drug is able to kill adult worms and whether post treatment microfilaria result from new infections. I also hope to dabble in transcriptomics/genomics from blood taken from S. mansoni infected individuals with an aim to understand infection profiles.
I also occasionally teach aspects of infection biology.
In my spare time, I like to fall off boulders and keep and breed cichlids.
WA Sands, MM Page, Selman C. (2018) Proteostasis and ageing. Insights from long lived mice. J. Physiol. 15(595):6383-90.
L Mulvey, WA Sands, K Salin, AE Carr, C Selman. (2017) Disentangling the effect of dietary restriction on mitochondrial function using recombinant inbred mice. Mol Cell Endocrinol. 5(455): 41-53.
F McManus F, W Sands, L Diver,SM MacKenzie, R Fraser, E Davies, JM Connell. (1012) APEX1 regulation of aldosterone synthase gene transcription is disrupted by a common polymorphism in humans. Circ Res 111(2):212-9.
WA Sands, HD Woolson, SJ Yarwood, TM Palmer. (2012) CCAAT/Enhancer Binding Proteins (C/EBPs) As Cyclic AMP-Activated Exchange Protein Activated By Cyclic AMP 1 (Epac1)-Regulated Transcription Factors Controlling Suppressor Of Cytokine Signalling-3 (SOCS-3) Induction. Methods in Molecular Biology 809:201-14.
KK Stevens, EP McQuarrie, W Sands, DZ Hillyard, RK Patel, PB Mark, AJ Jardine. (2011) Fibroblast growth factor 23 predicts left ventricular mass and induces cell adhesion molecule formation. Int. J. Nephrol Article ID 297070.
M Edward, JA Quin, W Sands. (2011) Keratinocytes stimulate fibroblast hyaluronan synthesis through the release of stratifin: a possible role in the suppression of scar tissue formation. Wound Repair Regen 19(3): 379-86.
GP Sandilands, H Wilson, C Huser, L Jolly, WA Sands, C McSharry. (2010) Were monocytes responsible for initiating the cytokine storm in the TGN1412 clinical trial tragedy? Clin. Exp. Immunol. 162(3): 516-27.
M Safhi, C Rutherford, C Ledent, WA Sands, TM Palmer. (2010) Priming of Signal Transducer and Activation of Transcription proteins for cytokine - triggered polyubiquitilation and degradation by the A2A Adenosine receptor. Mol. Pharmacol. 77 (6): 986-78.
WA Sands, HD Woolson, GR Milne, C Rutherford, TM Palmer. (2006) Exchange Protein Activated by Cyclic AMP (Epac)-Mediated Induction of Suppressor of Cytokine Signaling 3 (SOCS-3) in Vascular Endothelial Cells. Mol Cell Biol. Sep;26(17):6333-6346.
C Rutherford, FU Ord-Shrimpton, WA Sands, JD Pediani, JL Benovic, JC Mc Grath, TM Palmer. (2005) Phosphorylation-independent internalisation and desensitisation of the human sphingosine-1-phosphate receptor S1P3. Cell Signal. Aug;17(8):997-1009.
WA Sands, AF Martin, EW Strong, TM Palmer. (2004) Specific inhibition of NF-kB-dependent inflammatory responses by cell type-specific mechanisms by A2A adenosine receptor gene transfer. Mol Pharmacol. 66(5):1147-1159.
WA Sands, AF Martin, KR Watterson, TM Palmer. (2002) Molecular regulation of adenosine receptor signalling: implications for the design of novel cardioprotective and anti inflammatory therapies. Recent Dev. Mol. Pharmacol.,1, 53-75.
D Piedrafita, L Proudfoot, AV Nikolaev, D Xu, WA Sands, GJ Feng, E Thomas, J Brewer, MA Ferguson, J Alexander, FY Liew. (1999) Regulation of macrophage IL-12 synthesis by Leishmania phosphoglycans.Eur J Immunol. Jan;29(1):235-44.
FP Huang, D Xu, EO Efandiari, W Sands W, XQ Wei. FY Liew. (1998) Mice defective in Fas are highly susceptible to Leishmania major infection despite elevated IL-12 synthesis, strong Th1 responses, and enhanced nitric oxide production. J Immunol. May 1;160(9):4143-7.
WA Sands, V Bulut, AD Severin, D Xu, FY Liew. (1994) Inhibition of nitric oxide synthesis by interleukin-4 may involve inhibiting the activation of protein kinase C epsilon. Eur J Immunol. Oct;24(10):2345-50.
WA Sands, JS Clark, FY Liew. (1994) The role of a phosphatidylcholine-specific phospholipase C in the production of diacylglycerol for nitric oxide synthesis in macrophages activated by IFN-gamma and LPS. Biochem Biophys Res Commun. Mar 15;199(2):461-6.